Conference posters/abstracts

Here we describe a method to increase proteomic throughput by 10-times. The 10x increase in throughput increases possibilities for investigation into the spatial distribution of proteins throughout a tissue. We will next apply this methodology in order to determine spatial proteomic profiles of distinct histological features within a brain tumour. Abstract and Poster - 18th Human Proteome Organisation World Congress (HUPO2019), Australia, September 15th - 19th 2019.

The coupling of laser capture microdissection and proteomics is a powerful technique capable of generating reproducible, quantitative proteomes of sufficient depth from a single type of cell isolated from a mixed population, which has the potential to yield unbiased information about mechanisms of cell fate specification and degeneration in the human brain. Abstract and Poster - Human Proteome Organisation World Congress (HUPO2018), September 30th - October 03th 2018.

Used our developed micro-proteomic approach and applied it to ALS post mortem neurons. Abstract and Poster - ENCALS (European Network to Cure ALS) Meeting 2018.

Demonstrated proof of concept that Raman spectroscopy can be used for rapid, intraoperative glioma genetic classification. Abstract and Poster - The Internation Society for Clinical Spectroscopy (SPEC2018), Scotland, June 10th - 15th.

Summarised our group’s developed micro-proteomic approach and applied it to ALS post mortem neurons. Poster - University of Oxford’s Medical Science Division D.Phil Day 2018.

Demonstrated proof of concept that Raman spectroscopy can be used for rapid, intraoperative glioma genetic classification. Abstract and Poster - Cancer Research UK Brain Tumour Conference, England, June 1st - 3rd 2018.

Summarised our group’s developed micro-proteomic approach and applied it to ALS post mortem neurons. Poster - 9th Annual Oxford Neuroscience Symposium.

The coupling of laser capture microdissection and proteomics is a powerful technique capable of generating reproducible, quantitative proteomes of sufficient depth from a single type of cell isolated from a mixed population, which has the potential to yield unbiased information about mechanisms of cell fate specification and degeneration in the human brain. Abstract and Poster - 16th Human Proteome Organisation World Congress (HUPO2017), September 17th - 21st 2017.

Raman spectroscopy can accurately and rapidly distinguish IDH1 mutated glioblastomas from their IDH1 negative counterparts. Further work is currently being undertaken on fresh, intraoperative, tumour samples. Published Abstract (British Journal of Neurosurgery, vol 31, No. 2, 119-158 (2017))- Proceedings of the 2017 Spring Meeting of the Society of British Neurological Surgeons, Oxford, 29-31 March 2017.

Investigated the feasibility of using Raman spectroscopy to differentiate between IDH1 positive (IDH1 + ) and negative (IDH1 - ) tumours through classification modelling. Published Abstract & Poster - Journal of Neuro-Oncology (Volume 19).