Connor Scott

Connor Scott

Scientist (Alkermes) / Honorary Research Fellow (Oxford)

Alkermes

Nuffield Department of Clinical Neurosciences

Biography

Connor Scott is a seasoned neuroscientist with over 11 years of specialized expertise in ex vivo investigations, including extensive human tissue research, molecular biology, and mass spectrometry.

His career has been dedicated to unraveling the molecular complexities underlying neurodegenerative diseases through innovative research projects and drug discovery programs. His proficiency spans the fields of histology, neuropathology, neurobiology, and various multi-omics techniques.

He specializes in the following indications: Alzheimer’s Disease, Parkinson’s Disease, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Narcolepsy, Schizophrenia and Glioblastoma Multiforme.

Scroll down to see a brief overview of his professional profile or click on the headings above to see a detailed summary.

Interests

  • Drug Discovery / Drug Development
  • Cell Biology / Molecular Biology
  • Histology / Neuropathology
  • Neurodegeneration / Psychiatry
  • Proteomics / Transciptomics

Education

  • D.Phil/PhD in Clinical Neurosciences, 2021

    University of Oxford

  • BSc (Hons) in Biomedical Sciences, 2012

    University of Greenwich

Skills

qPCR

Neuropathology - Human Tissue

Proteomics / Transcriptomics

RNAscope / Immunostaining

Laser Microdissection

Molecular Biology

Data Analysis

Bioinformatics

Image Analysis

Employment Experience

 
 
 
 
 

Scientist - Functional Neuroanatomy

Alkermes

Jan 2023 – Present Boston
Alkermes is a global biopharmaceutical company developing innovative medicines in the fields of neurology and psychiatry with revenues north of ~$1 billion.

Overview of Position:

As a scientist within the CNS Biology Group, I lead ex vivo experiments using rodent and human brain tissue to support drug discovery and development. My multifaceted role spans several disciplines and incorporates a diverse range of techniques, including immunohistochemistry, in situ hybridization, spatial transcriptomics, receptor occupancy assessment, and MALDI Imaging.

Responsibilities include:

  • Demonstrating leadership in experimental design, planning, execution, and analysis.

  • Leveraging extensive expertise in human disease, neurobiology, and ex vivo investigations to advance preclinical drug programs by discovering suitable pharmacodynamic markers, determining target validation/engagement, and testing hypotheses to further understand the mechanism of action of different pharmaceuticals.

  • Collaborating with the wider R&D team to evaluate biochemical, molecular, and in vivo endpoints and providing strategic guidance to drive the progression of preclinical drug development.

  • Drive innovation through the adoption of cutting-edge techniques to better utilize human tissues, transgenic models, or animals dosed with different pharmacologies.

  • Provide project management for key research programs, including planning and overseeing experimental timelines, coordinating contracting, managing compound shipments, and ensuring timely delivery of final reports in collaboration with CROs.

  • Write and review technical documents for drug nomination and IND applications.
 
 
 
 
 

Honorary Academic

University of Oxford - Nuffield Department of Clinical Neurosciences

May 2021 – Present Oxford
Current projects:
Selective vulnerability of subpopulation of neurons in amyotrophic lateral sclerosis anf frontotemporal dementia.

Extracurricular

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Review Editor - Frontiers in Neuroanatomy

Frontiers in Neuroanatomy publishes research revealing important aspects of the anatomical organization of all nervous systems across all species.

Review Editor - Frontiers in Neuroimaging (Clinical Neuroimaging)

Frontiers in Neuroimaging is a multidisciplinary journal focused on expanding research on the physiological principles underlying typical and atypical brain functions to decrease the global burden of brain disorders.

Sir Charles Sherrington and Sir Wilfrid Le Gros Clark Collections

Digital microscopist for these historic collections.

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University of Oxford, Graduate President.

President of graduate students at one of University of Oxford’s colleges - Somerville College.

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University of Oxford, Social Secretary.

Responsible for planning, budgeting, and executing social activities at Somerville College.

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Neuropath EQA scheme (NEQAS)

The Neuropathology EQA scheme (NEQAS) forms part of a national system of quality assurance to healthcare organisations that is being maintained and improved.

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Editor - English Editing Service

With regards to scientific papers, MogoEdit provides two editing models: standard polishing and in-depth editing. Standard paper polishing mainly focuses on correcting errors in language, including word use, expressions, grammar, and sentence structure.

Recent Publications

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The Digital Brain Bank, an open access platform for post-mortem datasets

Post mortem MRI provides the opportunity to acquire high resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets.

Detection and quantification of novel C-terminal TDP-43 fragments in ALS-TDP

The pathological hallmark of amyotrophic lateral sclerosis (ALS) is the presence of cytoplasmic inclusions, containing C terminal …

Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP

Diffusion-weighted steady-state free precession (DW-SSFP) is an SNR-efficient diffusion imaging method. The improved SNR and resolution …

Conference Abstracts

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The microscopy connectome towards 3D PLI tractography in the BigMac dataset

Here, we reconstruct 3D fibre orientations from 2D microscopy images in the BigMac dataset. This will facilitate future determination of the ultra-high resolution microscopy connectome, with applications in basic neuroanatomy and tractography design.

Automatic extraction of reproducible semi-quantitative histological metrics for MRI-histology correlations

Here, we describe an end-to-end pipeline for the extraction of a histological metric from IHC stains to quantify a microstructural feature. We compare the pipeline’s reproducibility and robustness to histology artefacts, relative to manual MRI-histology analyses.

Spatially resolved MALDI mass spectrometric imaging of human brain tissue for metabolites, lipids, and peptides - proof of principle

In this proof of principle experiment, we demonstrate that MALDI-MSI combined with classical LCM LC-MS/MS has the potential to spatially resolve metabolic signatures in human brain at cellular resolution. Abstract & Talk given - The Oxford Metabolic Health Symposium 2020, 30th June – 3rd July 2020.

Molecular imaging of human brain tumour tissue by mass spectrometry

LC-MS based mass spectrometry imaging of proteins has the potential to provide novel insights into the proteome of tissues. Abstract - Presented at the Oxford Metabolic Health Symposium 2020, 30th June – 3rd July 2020.

High throughput, spatially-resolved proteomic analysis of a human brain tumour

Here we apply a sensitive, spatially resolved workflow for the proteomic analysis of a tumour to identify proteins that display spatial expression patterns within the tissue in an unsupervised manner. Abstract and Poster - ASMS Conference on Mass Spectrometry and Allied Topics, May 31st - June 4th 2020.