Cellular protein expression profiles within tissues are key to understanding disease pathology, and their spatial organisation determines cellular function. To precisely define molecular phenotypes in the spatial context of tissue, there is a need …
Here, we describe an end-to-end pipeline for the extraction of a histological metric from IHC stains to quantify a microstructural feature. We compare the pipeline's reproducibility and robustness to histology artefacts, relative to manual MRI-histology analyses.